Medical weight loss options have been on the up and up for some time simply because they work. Two of the most popular weight loss medications for this purpose are tirzepatide and semaglutide, both of which are type 2 diabetes drugs. Using tirzepatide and semaglutide off-label to aid in weight loss is becoming more commonplace these days, but how do you choose between tirzepatide and semaglutide, and what are the pros and cons of each? Ahead, we dive into the similarities and differences of tirzepatide vs semaglutide and what to know about each to make the right choice for you.
What Is Semaglutide?
Semaglutide is an injectable drug initially used as diabetes medication. It is now used to help patients lose weight in those who are overweight or clinically obese. Although semaglutide has shown promise, it is not considered a miracle treatment, nor is it for everyone.
Semaglutide is a type of medication known as glucagon-like peptide-1 receptor agonists or GLP1. It mimics the body’s natural activity of the GLP-1 hormone, released in the gut after eating. GLP-1’s job is to produce insulin and reduce blood sugar, which is why it is used to treat type 2 diabetes. However, GLP-1 communicates with the brain and tells when the stomach is full. Since GLP-1 in synthetic form suppresses the appetite, it can lead to weight loss in a controlled manner in those who have difficulty losing weight naturally.
What Is Tirzepatide?
Tirzepatide is similar to semaglutide in that it aids in weight loss but has a different chemical makeup. Known by its brand name, Mounjaro, tirzepatide is both a glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, which makes it different when discussing the differences between tirzepatide vs semaglutide. Like semaglutide, tirzepatide also mimics the action and functionality of the GLP-1 and GIP hormones, triggering insulin creation and the sensations of fullness.
One significant benefit of tirzepatide vs. semaglutide is that tirzepatide is likely to offer an extra boost in the weight loss department because it initiates GIP hormone activity. Some studies link tirzepatide to more effective weight loss than semaglutide, especially in those who are obese or overweight. Like semaglutide, it is also approved for type 2 diabetes use and is now used as a weight loss method.
Tirzepatide vs Semaglutide: The Dosage and Administration
Tirzepatide and semaglutide work towards the same end goal of weight loss, but the dosage and administration of each medication differ. Semaglutide is available as an oral tablet and injection, whereas tirzepatide is only available as an injection. However, both tirzepatide and semaglutide, despite their dosage and administration, are effective tools for weight loss.
In a clinical trial for tirzepatide, patients without type 2 diabetes who were looking to lose weight by taking the highest dose (15 milligrams) lost an average of 20.9% body weight over 72 weeks. In a trial for semaglutide, those on the medication without type 2 diabetes lost 14.9% of their initial body weight on average in 68 weeks.
Some patients also report a better overall experience when using tirzepatide vs semaglutide. However, it’s essential to know that the side effects of tirzepatide and semaglutide are similar and can include:
constipation and diarrhea
upset stomach, nausea, and vomiting
headaches
abdominal pain
fatigue
low blood sugar
allergic reactions
Cost and Availability
With all the buzz surrounding tirzepatide and semaglutide, there have been instances where availability has been scarce, which may be something to consider when deciding whether to take the medication. Your insurance may or may not cover some of the medication’s costs, which is essential to know before committing to the medication and determining which option is best for you.
Still, both tirzepatide and semaglutide come with high price tags ranging from $1,000 to $1,350 per month, depending on the medication you choose. Since these medications are taken weekly and long-term, the price will increase over time, which is something to consider. There are savings options and packages to take advantage of.
Frequently Asked Questions
How do tirzepatide and semaglutide work to promote weight loss?
Both tirzepatide and semaglutide are used with a healthy diet and regular exercise to help control blood sugar levels in adults with type 2 diabetes or to jumpstart weight loss. These medications can also help you reach your A1C goals, preventing diabetes.
What are the typical weight loss outcomes for patients using tirzepatide vs. semaglutide?
Most obese or overweight patients notice weight loss of about 10 to 22% of their body weight when using weight loss medications like tirzepatide and semaglutide. Even though these medications reduce your appetite and create a feeling of fullness, the effects are not immediate and must be dialed up to see the full potential.
What are the primary side effects of tirzepatide and semaglutide when used for weight loss?
Both tirzepatide and semaglutide are generally well tolerated, but there are some common side effects to be aware of. The most common side effects are nausea, diarrhea, and constipation, but tirzepatide has been found to potentially also cause vomiting and an increased risk of hypoglycemia.
How do the costs of tirzepatide and semaglutide compare for weight loss treatment?
Both tirzepatide and semaglutide are investments in your health, and neither comes cheap. However, semaglutide runs a few hundred dollars less per month than tirzepatide.
What should patients consider when choosing between Tirzepatide and Semaglutide for weight loss?
While semaglutide and tirzepatide are powerful tools for weight loss management, their results can be enhanced with a healthy lifestyle and dietary changes. Choosing between Semaglutide vs. Tirzepatide depends on your current state of health, goals, medications, and starting weight. Choosing between these medications should always be personalized.
Comentarios